The overall aim of unit is to contribute to improve the diagnosis and treatment of major neurological diseases or handicaps. These include neurodegenerative processes such as Alzheimer’s, Parkinson’s or Huntington diseases, stroke, anoxia, traumatic brain injury, brain tumors, and other acute or chronic conditions with neurological disorders leading to disabilities.

Most of our research program relies on neuroimaging and on brain stimulation and other techniques promoting cerebral plasticity, with the aim of improving recovery.

The main objectives of the ongoing project of the UMR 1214 TONIC are on the one hand to develop and adapt advanced neuroimaging techniques to translational and clinical research (team DEVIN), and, on the other hand, to couple these neuroimaging techniques to brain stimulation an re‐adaptation techniques in patients and controls for a better understanding of the pathophysiological mechanisms of the neurological disorders or handicaps (team iDREAM), so as to improve their early diagnosis and to define adapted therapeutic or rehabilitative approaches.

To reach our goals, we have access to two large instruments and sophisticated techniques on the Purpan hospital site: the PET Center which comprised a camera and a cyclotron currently owned and conducted by the University hospital (CHU), and the full‐research dedicated 3T MRI platform of the UMR 1214 TONIC, owned by the Inserm.


Neuroimaging , neurodegenerative diseases , neuro-oncology


2 teams :

  • DEVIN : DEveloppement et Validation de biomarqueurs en Irm et médecine Nucléaire
  • iDREAM: innovation in Drug, Regenerative mEdecine, stimulAtion, and modulation of Motor plasticity and recovery.


  • Human ressources 

Scientists (Researchers and Professors ) : 4 R / 23 P

Engineers, technical and administrative staff : 15

PhD students : 20 + 3 Post Doc


P. Payoux – DU - pierre.payoux@inserm.fr

M. Calise – Secrétaire de l’unité: maryline.calise@inserm.fr