S'identifier

MYC (Pathogenèse des infections à mycoplasmes)

MYC- pathogenesis of mycoplasmic infections

 

Mycoplasmas represent a large group of atypical bacteria which are characterised by having a reduced genome and an absence of cell wall.
In Ruminants they cause chronic illnesses in the respiratory and or reproductive systems. The methods of controlling these pathogens are usually ineffective leading to productivity loss. Contributing to new methods of control of mycoplasmic infections, the team’s objective is to understand the mechanisms which give the pathogens the means to colonise, survive and adapt in a host.

 

In order to address these issues they use an integrative approach combing:

  • Functional and comparative analysis of their genome,
  • Models of infections on a cellular level and experimentation in hosts
  • Using field data such as new strain infections, epidemiological data and host changes.

 

  1. Tardy F, Mick V, Dordet-Frisoni E, Marenda MS, Sirand-Pugnet P, Blanchard A, Citti C. Integrative conjugative elements are widespread in field isolates of Mycoplasma species pathogenic for ruminants. Appl Environ Microbiol. 2015 Mar;81(5):1634-43. doi: 10.1128/AEM.03723-14.
  2. Dordet-Frisoni E, Sagné E, Baranowski E, Breton M, Nouvel LX, Blanchard A, Marenda MS, Tardy F, Sirand-Pugnet P, Citti C. Chromosomal transfers in mycoplasmas: when minimal genomes go mobile. MBio. 2014 Nov 25;5(6):e01958. doi:  10.1128/mBio.01958-14.
  3. Baranowski, E., Bergonier, D., Sagne, É., Hygonenq, M. C., Ronsin, P., Berthelot, X., Citti, C. Experimental infections with Mycoplasma agalactiae identify key factors involved in host-colonization. Plos One, 9 (4). 2014 DOI : 10.1371/journal.pone.0093970
  4. Citti C, Blanchard A. Mycoplasmas and their host: emerging and re-emerging minimal pathogens. Trends Microbiol. 2013 Apr;21(4):196-203. doi: 10.1016/j.tim.2013.01.003.
  5. Tardy F, Baranowski E, Nouvel LX, Mick V, Manso-Silvàn L, Thiaucourt F, Thébault P, Breton M, Sirand-Pugnet P, Blanchard A, Garnier A, Gibert P, Game Y,  Poumarat F, Citti C. Emergence of atypical Mycoplasma agalactiae strains harboring a new prophage and associated with an alpine wild ungulate mortality episode. Appl Environ Microbiol. 2012 Jul;78(13):4659-68. doi: 10.1128/AEM.00332-12.        

Scientifiques : BARANOWSKI Eric (CR1, INRA), CITTI Christine (DR1, INRA) ; DORDET-FRISONI Emilie (CR2, INRA), BERGONIER Dominique (MC, ENVT), BERTHELOT Xavier (PR1, ENVT), NOUVEL Xavier (MC, ENVT) MAILLARD Renaud (MC, ENVT)

ITA : HYGONENQ Marie-Claude (TREX, INRA), MOYA Maria (ADJFR2, ENVT), SAGNE Eveline (IEFR, ENVT)

Christine Citti, responsable d’équipe, c.citti@envt.fr