The general objectives of the IRSD as a research institute are:

To develop new strategies for the diagnosis and treatment of digestive diseases.

To provide a productive, and innovative training environment.

To foster collaborations and interactions within the institute and outside of the institute.

The strategy is a comprehensive approach of digestive health: physiology, physiopathology, medical and molecular bacteriology, pharmacology, cell biology, epidemiology, immunology, neurosciences, genetics.

Facilities include experimental surgery and organoïds.


Intestinal physiopathology, host-bacteria interactions, antibioresistances.


Team  1 : Pathophysiology of intestinal epithelium (N. VERGNOLLE).

Team 2 :  Pathogenesis and commensalism of enterobacteria (E. OSWALD).

Team 3 : Neuro-immune intestinal interactions (G. DIETRICH).

Team 4 :Intestinal barrier functions : initiation and regulation (F. BARREAU).

Team 5 : Genetics and regulation of iron metabolism (H. ROTH et H. COPPIN).


Human ressources:

Permanent staff : 37

Contract staff : 15

Scientists  : 27

Engineers & technical staff : 18

PhD & PostDocs : 22


N. VERGNOLLE – Head  nathalie.vergnolle@inserm.fr

E. OSWALD – Vice-head  eric.oswald@inserm.fr

C. PETIT delegate for ENVT    claude.petit@inserm.fr