CYTOGENE: Cytogénomique Structurale et fonctionnelle



The « Cytogénomique Structurale et fonctionnelle » (Cytogene) team studies, in farm animals, the link between the genome structure and its transmission between cells or between individuals. It also studies how this structure affects the genome functioning. Finally, this team, with its expertise in structural cytogenetic, has a platform of chromosomal control of breeding populations in order to prevent the hypofertility of reproducers (swine and cattle mainly).

1. Nuclear architecture and chromatin interactions in pigs

2. Meiosis in vertebrates and epigenome during gametogenesis in link with farm animals fertility

3. Genomic and characterization of the genetic diversity of french honey bees (Apis Meliferra) populations

4. Structure of avian genomes


Congras A., Yerle-Bouissou M., Pinton A., Vignoles F., Liaubet L., Ferchaud S. and Acloque H. (2014) Sperm DNA Methylation Analysis in Swine Reveals Conserved and Species-Specific Methylation Patterns and Highlights an Altered Methylation at the GNAS Locus in Infertile Boars. Biology of Reproduction 91(6):137.

Mary N, Barasc H, Ferchaud S, Billon Y, Meslier F, Robelin D, Calgaro A, Loustau-Dudez AM, Bonnet N, Yerle M, Acloque H, Ducos A, Pinton A. (2014) Meiotic recombination analyses of individual chromosomes in male domestic pigs (Sus scrofa domestica). PLoS One.11;9(6):e99123. doi:10.1371/journal.pone.0099123.

Mompart F, Robelin D, Delcros C, Yerle-Bouissou M. 3D organization of telomeres in porcine neutrophils and analysis of LPS-activation effect. BMC Cell Biol. 2013;14:30. doi:10.1186/1471-2121-14-30.

Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y, Li J, Yi K, Feng H, Zhu P, Li B, Liu Q, Fairley S, Magor KE, Du Z, Hu X, Goodman L, Tafer H, Vignal A, et al.: The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. Nat Genet 2013, 45:776–783.

Rao M, Morisson M, Faraut T, Bardes S, Feve K, Labarthe E, Fillon V, Huang Y, Li N, Vignal A: A duck RH panel and its potential for assisting NGS genome assembly. BMC Genomics 2012, 13:513.


 15 agents permanents (*Agents basés sur le site de l’ENVT)

Scientifiques : H. Acloque (CR, INRA), M. Bouissou-Matet Yerle  (DR, INRA), A. Ducos* (PR, ENVT), V. Fillon (CR, INRA), A. Vignal (DR, INRA)

ITA : H. Barasc* (IE, ENVT), A. Calgaro* (TR, ENVT), K. Canale-Tabet (IE, INRA), E. Labarthe (TR, INRA), Y. Lahbib (IR, INRA), A.M. Loustau* (AI, INRA), N. Mary* (TR, INRA), F. Mompart (AI, INRA), N. Mouney* (TR, ENVT), A. Pinton* (IR, INRA).


Valérie Fillon, animatrice d’équipe : valerie.fillon@toulouse.inra.fr

Alain Ducos, directeur de la plateforme de contrôle chromosomique : a.ducos@envt.fr, labocyto@envt.fr


Link: http://genphyse.toulouse.inra.fr/